慢性肉芽肿病 (CGD)

概述

What is CGD?

Chronic granulomatous disease (CGD) is an inherited immune system disorder caused by improperly working white blood cells, called phagocytes. With CGD, phagocytes cannot protect the body from bacterial and fungal infections.

People with CGD are highly susceptible to frequent, sometimes life-threatening, bacterial and fungal infections. Infections may develop in the lungs, skin, lymph nodes, liver, stomach and intestines, or other areas. Masses of inflammatory tissue called granulomas may develop in response to these chronic infections.

Children with CGD are often healthy at birth but develop severe infections in infancy or early childhood. In rare cases, milder forms may not be diagnosed until adulthood.

How common is CGD?

CGD is rare, as it affects an estimated 1 in 200,000 to 250,000 people worldwide. In the United States, approximately 20 people are born with CGD each year, and it is more commonly found in males.

Questions regarding your CGD therapy?

You can reach the Accredo rare disease care team, anytime, day or night, seven days a week.

24 小时客户服务中心

Call 888-454-8860

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症状

What are the symptoms of CGD?

Most children with CGD are diagnosed by the age of 5.

People with CGD experience serious bacterial or fungal infection every few years. Lung infections, including pneumonia, are common. Exposure to dead leaves, mulch or hay poses a risk of a serious type of fungal pneumonia. Other common symptoms include:

  • Spleen and liver abscesses
  • Osteomyelitis: a bone infection
  • Septic arthritis: the invasion of a joint by a bacterial infection, which causes arthritis
  • Superficial skin infections, such as cellulitis and impetigo
  • Fungal infections
  • Swelling and redness in the mouth
  • Gastrointestinal problems

如何诊断？

To diagnose CGD, a physician may ask about your family medical history and order several tests including:

  • Physical exam to look for inflammation and granulomas.
  • Blood tests showing how well phagocytes produce hydrogen peroxide, an indicator that they are functioning properly.
  • Genetic testing to identify a faulty gene that causes CGD.

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药品

The following specialty medications are available at Accredo, a specialty pharmacy for chronic granulomatous disease.

药品 生产商
Actimmune®（干扰素 γ-1b） Horizon Pharma, Inc.

节约护理费用

您还可获得财政资源援助，以承担您的部分药品费用，包括生产商和社区计划。 You may also use the copay assistance search for additional programs. Accredo 专家可以帮助您找到适合您的计划。

财政指导

查找支持

There are many organizations that support research and advocacy for CGD. 下面是其中部分组织。

支持组织

团队介绍

Accredo’s rare disease care team is dedicated to serving you, and we understand the complexity of your condition. 我们的特殊培训临床医师每周 7 天、每天 24 小时为您提供服务，以回答您的任何问题。

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Accredo 为慢性和复杂病症患者提供支持，并帮助他们过上最好的生活。请观看我们的视频，了解我们为什么为患者尽心尽力。

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24 小时客户服务中心

Call 888-454-8860